Pankbase connects and integrates pancreas and islet datasets generated through international tissue mapping efforts.

U24DK138512

Ying Sun

A Data and Administrative Coordinating Center for the PanKbase Consortium

Kyle Gaulton

pankbase-consortium

Pankbase Consortium, PanKbase

CHEBI:145800

A quinolone that is 4-quinolone substituted at positions 1, 3, 5, 6 and 7 by ethyl, carboxy, amino, fluorine, and cyclohexylamino groups, respectively. It can directly bind to and block the transcription activity of the active forkhead box protein O1 (Foxo1), but not the Ser256-phosphorylated form. It induces cell death and growth arrest in Burkitt lymphoma cell lines at low concentrations.

Treatment of 10 μM FOXO inhibitor AS1842856

CHEBI:145800

Attribution