CHEBI:145800

{
    "@context": "/terms/",
    "@id": "/treatments/681129c2-d2b0-444f-8cc2-b11210edaa4a/",
    "@type": [
        "Treatment",
        "Item"
    ],
    "aliases": [
        "pankbase-consortium:treatment_FOXOinhibitorAS1842856"
    ],
    "amount": 10,
    "amount_units": "μM",
    "audit": {
        "INTERNAL_ACTION": [
            {
                "category": "mismatched status",
                "detail": "Released treatment [681129c2-d2b0-444f-8cc2-b11210edaa4a](/treatments/681129c2-d2b0-444f-8cc2-b11210edaa4a/) has deleted subobject award [U24DK13851](/awards/U24DK13851/).",
                "level": 30,
                "level_name": "INTERNAL_ACTION",
                "name": "audit_item_status",
                "path": "/treatments/681129c2-d2b0-444f-8cc2-b11210edaa4a/"
            }
        ]
    },
    "award": {
        "@id": "/awards/U24DK13851/",
        "component": "data coordination"
    },
    "biosamples_treated": [],
    "creation_timestamp": "2025-01-07T18:56:07.048478+00:00",
    "depletion": false,
    "description": "A quinolone that is 4-quinolone substituted at positions 1, 3, 5, 6 and 7 by ethyl, carboxy, amino, fluorine, and cyclohexylamino groups, respectively. It can directly bind to and block the transcription activity of the active forkhead box protein O1 (Foxo1), but not the Ser256-phosphorylated form. It induces cell death and growth arrest in Burkitt lymphoma cell lines at low concentrations.",
    "lab": {
        "@id": "/labs/pankbase-consortium/",
        "title": "Pankbase Consortium, PanKbase"
    },
    "notes": "From study GSE142465",
    "purpose": "stimulation",
    "release_timestamp": "2025-01-10T09:35:13.908313+00:00",
    "schema_version": "7",
    "status": "released",
    "submitted_by": {
        "@id": "/users/5e3038c4-baa5-4589-b3d8-ad2fe634e826/",
        "title": "Ying Sun"
    },
    "submitter_comment": "https://genomebiology.biomedcentral.com/articles/10.1186/s13059-020-02006-2#Sec10",
    "summary": "Treatment of 10 μM FOXO inhibitor AS1842856",
    "treatment_term_id": "CHEBI:145800",
    "treatment_term_name": "FOXO inhibitor AS1842856",
    "treatment_type": "chemical",
    "uuid": "681129c2-d2b0-444f-8cc2-b11210edaa4a"
}