U24DK138512-DK138515

Ying Sun

A Data and Administrative Coordinating Center for the PanKbase Consortium U24DK138512-DK138515

pankbase-consortium

CHEBI:9516

An organic heterotricyclic compound that is a hexa-oxygenated 6,7-guaianolide isolated fron the roots of Thapsia garganica L., Apiaceae. A potent skin irritant, it is used in traditional medicine as a counter-irritant. Thapsigargin inhibits Ca2+-transporting ATPase mediated uptake of calcium ions into sarcoplasmic reticulum and is used in experimentation examining the impacts of increasing cytosolic calcium concentrations.

Treatment of 0 μM thapsigargin for 2 hours