CHEBI:9516

{
    "@context": "/terms/",
    "@id": "/treatments/93567b30-eb7c-495f-ad68-ec2dac5d9a34/",
    "@type": [
        "Treatment",
        "Item"
    ],
    "aliases": [
        "pankbase-consortium:treatment_Thapsigargin"
    ],
    "amount": 250,
    "amount_units": "nM",
    "audit": {},
    "award": {
        "@id": "/awards/U24DK138512/",
        "component": "data coordination"
    },
    "biosamples_treated": [],
    "creation_timestamp": "2025-05-06T22:06:47.595613+00:00",
    "depletion": false,
    "description": "An organic heterotricyclic compound that is a hexa-oxygenated 6,7-guaianolide isolated fron the roots of Thapsia garganica L., Apiaceae. A potent skin irritant, it is used in traditional medicine as a counter-irritant. Thapsigargin inhibits Ca2+-transporting ATPase mediated uptake of calcium ions into sarcoplasmic reticulum and is used in experimentation examining the impacts of increasing cytosolic calcium concentrations.",
    "lab": {
        "@id": "/labs/pankbase-consortium/",
        "title": "Pankbase Consortium, PanKbase"
    },
    "purpose": "stimulation",
    "release_timestamp": "2025-06-15T06:27:09.660485+00:00",
    "schema_version": "7",
    "status": "released",
    "submitted_by": {
        "@id": "/users/5e3038c4-baa5-4589-b3d8-ad2fe634e826/",
        "title": "Ying Sun"
    },
    "submitter_comment": "https://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI:9516",
    "summary": "Treatment of 250 nM thapsigargin",
    "treatment_term_id": "CHEBI:9516",
    "treatment_term_name": "thapsigargin",
    "treatment_type": "chemical",
    "uuid": "93567b30-eb7c-495f-ad68-ec2dac5d9a34"
}