CHEBI:145800

{
    "@context": "/terms/",
    "@id": "/treatments/686c323c-e56b-4560-a5a0-683b0b318142/",
    "@type": [
        "Treatment",
        "Item"
    ],
    "aliases": [
        "pankbase-consortium:treatment_FOXOinhibitorAS1842856_72hr"
    ],
    "amount": 10,
    "amount_units": "μM",
    "audit": {},
    "award": {
        "@id": "/awards/U24DK138512-DK138515/",
        "component": "data coordination"
    },
    "biosamples_treated": [
        "/primary-islet/PKBSM3019ZJKF/"
    ],
    "creation_timestamp": "2026-02-05T00:14:29.016861+00:00",
    "depletion": false,
    "description": "A quinolone that is 4-quinolone substituted at positions 1, 3, 5, 6 and 7 by ethyl, carboxy, amino, fluorine, and cyclohexylamino groups, respectively. It can directly bind to and block the transcription activity of the active forkhead box protein O1 (Foxo1), but not the Ser256-phosphorylated form. It induces cell death and growth arrest in Burkitt lymphoma cell lines at low concentrations.",
    "duration": 72,
    "duration_units": "hour",
    "lab": {
        "@id": "/labs/pankbase-consortium/"
    },
    "notes": "From study GSE142465",
    "purpose": "stimulation",
    "release_timestamp": "2026-02-05T23:05:14.436057+00:00",
    "schema_version": "7",
    "status": "released",
    "submitted_by": {
        "@id": "/users/5e3038c4-baa5-4589-b3d8-ad2fe634e826/",
        "title": "Ying Sun"
    },
    "submitter_comment": "https://genomebiology.biomedcentral.com/articles/10.1186/s13059-020-02006-2#Sec10",
    "summary": "Treatment of 10 μM FOXO inhibitor AS1842856 for 72 hours",
    "treatment_term_id": "CHEBI:145800",
    "treatment_term_name": "FOXO inhibitor AS1842856",
    "treatment_type": "chemical",
    "uuid": "686c323c-e56b-4560-a5a0-683b0b318142"
}