islet of Langerhans — PKBSM6983NHDE

{
    "@context": "/terms/",
    "@id": "/primary-islet/PKBSM6983NHDE/",
    "@type": [
        "PrimaryIslet",
        "Biosample",
        "Sample",
        "Item"
    ],
    "accession": "PKBSM6983NHDE",
    "age": "unknown",
    "aliases": [
        "macdonald:R427_bulkIslet_secondaryBiosample_Interleukin1beta_Interferongamma_difluoromethylornithinefor24hr"
    ],
    "audit": {
        "WARNING": [
            {
                "category": "missing tier 2 field",
                "detail": "Human donor [PKBSM6983NHDE](/primary-islet/PKBSM6983NHDE/) is missing tier 2 field `rrid`.",
                "level": 40,
                "level_name": "WARNING",
                "name": "audit_desired_fields",
                "path": "/primary-islet/PKBSM6983NHDE/"
            },
            {
                "category": "missing tier 2 field",
                "detail": "Human donor [PKBSM6983NHDE](/primary-islet/PKBSM6983NHDE/) is missing tier 2 field `organ_source`.",
                "level": 40,
                "level_name": "WARNING",
                "name": "audit_desired_fields",
                "path": "/primary-islet/PKBSM6983NHDE/"
            },
            {
                "category": "missing tier 2 field",
                "detail": "Human donor [PKBSM6983NHDE](/primary-islet/PKBSM6983NHDE/) is missing tier 2 field `prep_viability`.",
                "level": 40,
                "level_name": "WARNING",
                "name": "audit_desired_fields",
                "path": "/primary-islet/PKBSM6983NHDE/"
            },
            {
                "category": "missing tier 2 field",
                "detail": "Human donor [PKBSM6983NHDE](/primary-islet/PKBSM6983NHDE/) is missing tier 2 field `warm_ischaemia_duration`.",
                "level": 40,
                "level_name": "WARNING",
                "name": "audit_desired_fields",
                "path": "/primary-islet/PKBSM6983NHDE/"
            },
            {
                "category": "missing tier 2 field",
                "detail": "Human donor [PKBSM6983NHDE](/primary-islet/PKBSM6983NHDE/) is missing tier 2 field `hand_picked`.",
                "level": 40,
                "level_name": "WARNING",
                "name": "audit_desired_fields",
                "path": "/primary-islet/PKBSM6983NHDE/"
            },
            {
                "category": "missing tier 2 field",
                "detail": "Human donor [PKBSM6983NHDE](/primary-islet/PKBSM6983NHDE/) is missing tier 2 field `pre_shipment_culture_time`.",
                "level": 40,
                "level_name": "WARNING",
                "name": "audit_desired_fields",
                "path": "/primary-islet/PKBSM6983NHDE/"
            },
            {
                "category": "missing tier 2 field",
                "detail": "Human donor [PKBSM6983NHDE](/primary-islet/PKBSM6983NHDE/) is missing tier 2 field `islet_function_available`.",
                "level": 40,
                "level_name": "WARNING",
                "name": "audit_desired_fields",
                "path": "/primary-islet/PKBSM6983NHDE/"
            }
        ]
    },
    "award": {
        "@id": "/awards/5-SRA-2021-1149-S-B/"
    },
    "biosample_type": "Post-shipment",
    "classifications": [
        "primary islet"
    ],
    "cold_ischaemia_time": -999,
    "creation_timestamp": "2025-10-17T00:39:28.610496+00:00",
    "description": "Post-shipment treatment of islet biosample from human donor R427, IL1b, IFNy, DFMO for 24 hr",
    "donors": [
        {
            "@id": "/human-donors/PKBDO8937MLMW/",
            "accession": "PKBDO8937MLMW",
            "age": 52,
            "gender": "Male",
            "summary": "PKBDO8937MLMW",
            "taxa": "Homo sapiens"
        }
    ],
    "file_sets": [
        {
            "@id": "/measurement-sets/PKBDS5911IXUZ/",
            "accession": "PKBDS5911IXUZ",
            "aliases": [
                "pankbase-consortium:bulkIslets_GSE226888_R427_Interleukin1beta_Interferongamma_difluoromethylornithinefor24hr_MeasurementSet"
            ],
            "assay_term": {
                "term_name": "bulk RNA-seq assay"
            },
            "lab": {},
            "status": "released"
        },
        {
            "@id": "/analysis-sets/PKBDS1007CQKS/",
            "accession": "PKBDS1007CQKS",
            "aliases": [
                "pankbase-consortium:bulkIslets_GSE226888_R427_Interleukin1beta_Interferongamma_difluoromethylornithinefor24hr_AnalysisSet"
            ],
            "lab": {},
            "status": "released"
        }
    ],
    "institutional_certificates": [],
    "isolation_center": "ADI – Alberta Diabetes Institute",
    "lab": {
        "@id": "/labs/patrick-macdonald/"
    },
    "multiplexed_in": [],
    "origin_of": [],
    "originated_from": "/primary-islet/PKBSM2949BGOL/",
    "parts": [],
    "pooled_in": [],
    "purity": [
        "-"
    ],
    "release_timestamp": "2025-10-27T19:41:26.847902+00:00",
    "sample_terms": [
        {
            "@id": "/sample-terms/UBERON_0000006/",
            "term_name": "islet of Langerhans"
        }
    ],
    "schema_version": "19",
    "sex": "Male",
    "sorted_fractions": [],
    "sources": [
        {
            "@id": "/labs/patrick-macdonald/"
        }
    ],
    "status": "released",
    "submitted_by": {
        "@id": "/users/5e3038c4-baa5-4589-b3d8-ad2fe634e826/",
        "title": "Ying Sun"
    },
    "submitter_comment": "From GEO record GSE226888",
    "summary": "islet of Langerhans cell, Male, Homo sapiens treated with 0 μM Interferon gamma for 24 hours, 0 μM Interleukin-1 beta for 24 hours, 0 μM difluoromethylornithine for 24 hours",
    "treatments": [
        {
            "@id": "/treatments/7f1cf24f-6100-4d38-bc5b-37db27528a87/",
            "purpose": "stimulation",
            "status": "released",
            "summary": "Treatment of 0 μM Interleukin-1 beta for 24 hours",
            "treatment_type": "protein"
        },
        {
            "@id": "/treatments/ece200cd-e469-4983-bc3f-d93a65c36e4d/",
            "purpose": "stimulation",
            "status": "released",
            "summary": "Treatment of 0 μM Interferon gamma for 24 hours",
            "treatment_type": "protein"
        },
        {
            "@id": "/treatments/658a519d-becb-4757-b875-1dbaf7d64651/",
            "purpose": "perturbation",
            "status": "released",
            "summary": "Treatment of 0 μM difluoromethylornithine for 24 hours",
            "treatment_type": "chemical"
        }
    ],
    "uuid": "05e6d8af-24ba-489f-b112-0ef59a0e436c",
    "virtual": false
}