PKBDO9533OULN
{
"@context": "/terms/",
"@id": "/human-donors/PKBDO9533OULN/",
"@type": [
"HumanDonor",
"Donor",
"Item"
],
"aab_count": 1,
"aab_gada": true,
"aab_gada_assay": [
"1"
],
"aab_gada_value": 751,
"aab_ia2": false,
"aab_ia2_assay": [],
"aab_ia2_value": 0,
"aab_iaa": false,
"aab_iaa_assay": [],
"aab_iaa_value": -0.001,
"aab_positive": true,
"aab_summary": "GADA+",
"aab_tested": true,
"aab_znt8": false,
"aab_znt8_assay": [],
"aab_znt8_value": 0,
"accession": "PKBDO9533OULN",
"age": 30,
"age_group": "18-39",
"aliases": [
"klaus-kaestner:HPAP-017"
],
"audit": {
"WARNING": [
{
"category": "missing tier 1 field",
"detail": "Human donor [PKBDO9533OULN](/human-donors/PKBDO9533OULN/) is missing tier 1 field `sex`.",
"level": 40,
"level_name": "WARNING",
"name": "audit_tier1_fields",
"path": "/human-donors/PKBDO9533OULN/"
},
{
"category": "missing tier 2 field",
"detail": "Human donor [PKBDO9533OULN](/human-donors/PKBDO9533OULN/) is missing tier 2 field `glucose_loweing_theraphy`.",
"level": 40,
"level_name": "WARNING",
"name": "audit_tier2_fields",
"path": "/human-donors/PKBDO9533OULN/"
},
{
"category": "missing tier 3 field",
"detail": "Human donor [PKBDO9533OULN](/human-donors/PKBDO9533OULN/) is missing tier 3 field `phenotypic_features`.",
"level": 40,
"level_name": "WARNING",
"name": "audit_tier3_fields",
"path": "/human-donors/PKBDO9533OULN/"
},
{
"category": "missing tier 3 field",
"detail": "Human donor [PKBDO9533OULN](/human-donors/PKBDO9533OULN/) is missing tier 3 field `family_history_of_diabetes_relationship`.",
"level": 40,
"level_name": "WARNING",
"name": "audit_tier3_fields",
"path": "/human-donors/PKBDO9533OULN/"
},
{
"category": "missing tier 3 field",
"detail": "Human donor [PKBDO9533OULN](/human-donors/PKBDO9533OULN/) is missing tier 3 field `diabetes_duration`.",
"level": 40,
"level_name": "WARNING",
"name": "audit_tier3_fields",
"path": "/human-donors/PKBDO9533OULN/"
},
{
"category": "missing tier 3 field",
"detail": "Human donor [PKBDO9533OULN](/human-donors/PKBDO9533OULN/) is missing tier 3 field `other_therapy`.",
"level": 40,
"level_name": "WARNING",
"name": "audit_tier3_fields",
"path": "/human-donors/PKBDO9533OULN/"
},
{
"category": "missing tier 3 field",
"detail": "Human donor [PKBDO9533OULN](/human-donors/PKBDO9533OULN/) is missing tier 3 field `documents`.",
"level": 40,
"level_name": "WARNING",
"name": "audit_tier3_fields",
"path": "/human-donors/PKBDO9533OULN/"
},
{
"category": "missing tier 3 field",
"detail": "Human donor [PKBDO9533OULN](/human-donors/PKBDO9533OULN/) is missing tier 3 field `related_donors`.",
"level": 40,
"level_name": "WARNING",
"name": "audit_tier3_fields",
"path": "/human-donors/PKBDO9533OULN/"
}
]
},
"award": {
"@id": "/awards/UC4DK112217/",
"name": "UC4DK112217",
"title": "PENN INTEGRATED HUMAN PANCREAS PROCUREMENT AND ANALYSIS PROGRAM"
},
"biosamples": [
"/primary-islet/PKBSM8928EEBO/",
"/primary-cells/PKBSM9902FNTE/",
"/primary-cells/PKBSM9774DXVE/",
"/primary-cells/PKBSM7682HQMK/",
"/primary-islet/PKBSM8070ZRUS/"
],
"bmi": 23.7,
"c_peptide": 3.71,
"cause_of_death": "Anoxia",
"center_donor_id": "SAMN19776448",
"collections": [
"HPAP"
],
"creation_timestamp": "2024-10-14T22:30:17.662355+00:00",
"data_available": [
{
"dataset": "Genotyping",
"dataset_link": "https://www.ncbi.nlm.nih.gov/projects/gap/cgi-bin/study.cgi?study_id=phs002465.v1.p1",
"dataset_tissue": "-"
},
{
"dataset": "HLA_typing",
"dataset_link": "https://www.ncbi.nlm.nih.gov/projects/gap/cgi-bin/study.cgi?study_id=phs002465.v1.p1",
"dataset_tissue": "-"
},
{
"dataset": "RNAseq",
"dataset_link": "https://hpap.pmacs.upenn.edu",
"dataset_tissue": "Islet"
},
{
"dataset": "ATAC-seq",
"dataset_link": "https://hpap.pmacs.upenn.edu",
"dataset_tissue": "Islet"
},
{
"dataset": "Function",
"dataset_link": "https://hpap.pmacs.upenn.edu",
"dataset_tissue": "Islet"
},
{
"dataset": "Imaging",
"dataset_link": "https://hpap.pmacs.upenn.edu",
"dataset_tissue": "Islet"
},
{
"dataset": "Morphology",
"dataset_link": "https://hpap.pmacs.upenn.edu",
"dataset_tissue": "Islet"
},
{
"dataset": "CyTof",
"dataset_link": "https://hpap.pmacs.upenn.edu",
"dataset_tissue": "Islet"
},
{
"dataset": "WGBS",
"dataset_link": "https://hpap.pmacs.upenn.edu",
"dataset_tissue": "Islet"
},
{
"dataset": "histology",
"dataset_link": "https://hpap.pmacs.upenn.edu",
"dataset_tissue": "Pancreas"
},
{
"dataset": "CODEX",
"dataset_link": "https://hpap.pmacs.upenn.edu",
"dataset_tissue": "Pancreas"
},
{
"dataset": "imaging_mass_spec",
"dataset_link": "https://hpap.pmacs.upenn.edu",
"dataset_tissue": "Pancreas"
},
{
"dataset": "TCRseq",
"dataset_link": "https://hpap.pmacs.upenn.edu",
"dataset_tissue": "Spleen"
},
{
"dataset": "BCRseq",
"dataset_link": "https://hpap.pmacs.upenn.edu",
"dataset_tissue": "Spleen"
},
{
"dataset": "Flow_cytometry",
"dataset_link": "https://hpap.pmacs.upenn.edu",
"dataset_tissue": "Spleen"
},
{
"dataset": "histology",
"dataset_link": "https://hpap.pmacs.upenn.edu",
"dataset_tissue": "Spleen"
},
{
"dataset": "Flow_cytometry",
"dataset_link": "https://hpap.pmacs.upenn.edu",
"dataset_tissue": "Lymph"
},
{
"dataset": "histology",
"dataset_link": "https://hpap.pmacs.upenn.edu",
"dataset_tissue": "Lymph"
},
{
"dataset": "Flow_cytometry",
"dataset_link": "https://hpap.pmacs.upenn.edu",
"dataset_tissue": "Peripheral_blood"
}
],
"data_available_datasets": [
"Genotyping",
"HLA_typing",
"RNAseq",
"ATAC-seq",
"Function",
"Imaging",
"Morphology",
"CyTof",
"WGBS",
"Histology",
"CODEX",
"imaging_mass_spec",
"TCRseq",
"BCRseq",
"Flow_cytometry"
],
"data_available_keys": [
"Genotyping|unspecified",
"HLA_typing|unspecified",
"RNAseq|Islet",
"ATAC-seq|Islet",
"Function|Islet",
"Imaging|Islet",
"Morphology|Islet",
"CyTof|Islet",
"WGBS|Islet",
"Histology|Pancreas",
"CODEX|Pancreas",
"imaging_mass_spec|Pancreas",
"TCRseq|Spleen",
"BCRseq|Spleen",
"Flow_cytometry|Spleen",
"Histology|Spleen",
"Flow_cytometry|Lymph",
"Histology|Lymph",
"Flow_cytometry|Peripheral_blood"
],
"data_available_tissues": [
"unspecified",
"Islet",
"Pancreas",
"Spleen",
"Lymph",
"Peripheral_blood"
],
"dbxrefs": [
"PANC-DB:HPAP-017"
],
"derived_diabetes_status": "Normal",
"description": "Human pancreas donor SAMN19776448 in the HPAP database",
"diabetes_status": [],
"diabetes_status_description": "Control Without Diabetes",
"dominant_genetic_ancestry": "European",
"donation_type": "Donation after brain death",
"ethnicities": [
"White"
],
"family_history_of_diabetes": "FALSE",
"gender": "Male",
"genetic_ethnicities": [
{
"ethnicity": "European",
"percentage": 98
},
{
"ethnicity": "Admixed-American",
"percentage": 2
}
],
"genetic_sex": "Male",
"hba1c": 5.5,
"hla_typing": [
"A,01:01-11:01,NGS",
"A,1-11,RT-PCR",
"B,08:01-44:03,NGS",
"B,8-44,RT-PCR",
"Bw4,1-.,RT-PCR",
"Bw6,1-.,RT-PCR",
"C,07:01-16:01,NGS",
"C,7-16,RT-PCR",
"DPA,01-02,RT-PCR",
"DPA1,01:03-02:01,NGS",
"DPB,03-11,RT-PCR",
"DPB1,11:01-104:01,NGS",
"DQA,02-05,RT-PCR",
"DQA1,02:01-05:01,NGS",
"DQB,2-2,RT-PCR",
"DQB1,02:01-02:02,NGS",
"DR,7-17,RT-PCR",
"DR51,0-.,RT-PCR",
"DR52,1-.,RT-PCR",
"DR53,1-.,RT-PCR",
"DRB1,03:01-07:01,NGS",
"DRB3,01:01-.,NGS",
"DRB4,.-01:01,NGS",
"DRB5,.-.,NGS"
],
"hospital_stay": 131,
"human_donor_identifiers": [
"PANC-DB:HPAP-017"
],
"lab": {
"@id": "/labs/klaus-kaestner/"
},
"label_hba1c_discordant": false,
"living_donor": false,
"other_tissues_available": [
"/sample-terms/UBERON_0002113/",
"/sample-terms/UBERON_0002107/",
"/sample-terms/UBERON_0001264/"
],
"pancreas_tissue_available": true,
"pediatric": false,
"publication_identifiers": [
"PMID:31127054",
"PMID:36206763"
],
"release_timestamp": "2025-01-10T01:41:06.166911+00:00",
"rrid": "RRID:SAMN19776448",
"schema_version": "23",
"sex_discordant": false,
"status": "released",
"submitted_by": {
"@id": "/users/5e3038c4-baa5-4589-b3d8-ad2fe634e826/",
"title": "Ying Sun"
},
"submitter_comment": "Meta-data was obtained directly from PANC-DB",
"summary": "PKBDO9533OULN",
"t1d_stage": "At-risk: single or transient autoantibody, normal glucose level",
"taxa": "Homo sapiens",
"tier1_complete": false,
"url": "https://hpap.pmacs.upenn.edu/explore/donor/donor-summary/HPAP-017",
"uuid": "a40f0e2f-1b6f-4ef8-ad04-ab6ed7372a65",
"virtual": false
}
Supported by National Institutes of Health (NIH) grants U24 DK138515, U24 DK138512
Supplemental funds from the NIH Office of Data Science Strategies
Supplemental funds from the NIH Office of Data Science Strategies
