released

PKBDO9514HUCG

released

RRID RRID:SAMN19776454Program Donor ID SAMN19776454

Clinical summary

Diabetes status

Type 1 Diabetes

Age (y)

Age group

13-17

BMI

21.35

Height (cm)

—

Weight (kg)

—

HbA1c %

8.9

C-Peptide (ng/ml)

0.02

Diabetes duration

AAB summary

IAA+

AAB count

Age (y): 17
Age group: 13-17
Pediatric: Yes
Gender: Female
Genetic Sex: Female
Sex discordant: No
Ethnicity: White
Predicted genetic ancestry: European (96%), East-Asian (2%), African (1%), Admixed-American (1%)
Dominant genetic ancestry: European

Diabetes (ontology): MONDO:0005147
T1D stage: Stage 3: one or more autoantibodies and diagnostic hyperglycemia or T1D diagnosis
HbA1c-derived diabetes status: Diabetes
Label vs HbA1c discordant: No
Tier 1 complete: Yes
Family history of diabetes: -
Living donor: No
Cause of death: Anoxia/DKA
Donation type: Donation after circulatory death
Hospital stay (h): 63
Medication: Insulin

GADANegative

2 unit/ml

IAAPositive

0.835 unit/ml

IA2Negative

0 unit/ml

ZNT8Negative

0 unit/ml

Locus	Allele 1	Allele 2	Method
A	02:01	33:01	NGS
A	02:01	33:01	RT-PCR
B	08:01	14:02	NGS
B	08:01	14:02	RT-PCR
C	07:01	08:02	NGS
C	07:01	08:02	RT-PCR
DPA1	01:03	—	NGS
DPA1	01:03	—	RT-PCR
DPB1	04:01	34:01	NGS
DPB1	04:01	34:01	RT-PCR
DQA1	01:01	05:01	NGS
DQA1	01:01	05:01	RT-PCR
DQB1	02:01	05:01	NGS
DQB1	02:01	05:01	RT-PCR
DRB1	01:02	03:01	NGS
DRB1	01:02	03:01	RT-PCR
DRB3	—	01:01	NGS
DRB3	01:01	—	RT-PCR
DRB4	—	—	NGS
DRB4	—	—	RT-PCR

Datasets: Genotyping, HLA_typing, scRNAseq, CyTof, Histology, CODEX, imaging_mass_spec, scMultiome, snATACseq, TCRseq, BCRseq, CITEseq, Flow_cytometry
Tissues: unspecified, Islet, Pancreas, Spleen, Lymph, Peripheral_blood