PKBDO8380DZQP
{
"@context": "/terms/",
"@id": "/human-donors/PKBDO8380DZQP/",
"@type": [
"HumanDonor",
"Donor",
"Item"
],
"aab_count": 0,
"aab_gada": false,
"aab_gada_assay": [],
"aab_gada_value": 0,
"aab_ia2": false,
"aab_ia2_assay": [],
"aab_ia2_value": 0,
"aab_iaa": false,
"aab_iaa_assay": [],
"aab_iaa_value": 0.001,
"aab_positive": false,
"aab_summary": "none positive",
"aab_tested": true,
"aab_znt8": false,
"aab_znt8_assay": [],
"aab_znt8_value": -0.001,
"accession": "PKBDO8380DZQP",
"age": 55,
"age_group": "40-64",
"aliases": [
"klaus-kaestner:HPAP-106"
],
"audit": {
"WARNING": [
{
"category": "missing tier 1 field",
"detail": "Human donor [PKBDO8380DZQP](/human-donors/PKBDO8380DZQP/) is missing tier 1 field `sex`.",
"level": 40,
"level_name": "WARNING",
"name": "audit_tier1_fields",
"path": "/human-donors/PKBDO8380DZQP/"
},
{
"category": "missing tier 2 field",
"detail": "Human donor [PKBDO8380DZQP](/human-donors/PKBDO8380DZQP/) is missing tier 2 field `glucose_loweing_theraphy`.",
"level": 40,
"level_name": "WARNING",
"name": "audit_tier2_fields",
"path": "/human-donors/PKBDO8380DZQP/"
},
{
"category": "missing tier 3 field",
"detail": "Human donor [PKBDO8380DZQP](/human-donors/PKBDO8380DZQP/) is missing tier 3 field `phenotypic_features`.",
"level": 40,
"level_name": "WARNING",
"name": "audit_tier3_fields",
"path": "/human-donors/PKBDO8380DZQP/"
},
{
"category": "missing tier 3 field",
"detail": "Human donor [PKBDO8380DZQP](/human-donors/PKBDO8380DZQP/) is missing tier 3 field `documents`.",
"level": 40,
"level_name": "WARNING",
"name": "audit_tier3_fields",
"path": "/human-donors/PKBDO8380DZQP/"
},
{
"category": "missing tier 3 field",
"detail": "Human donor [PKBDO8380DZQP](/human-donors/PKBDO8380DZQP/) is missing tier 3 field `related_donors`.",
"level": 40,
"level_name": "WARNING",
"name": "audit_tier3_fields",
"path": "/human-donors/PKBDO8380DZQP/"
}
]
},
"award": {
"@id": "/awards/U01DK123594/",
"name": "U01DK123594",
"title": "THE HUMAN PANCREAS ANALYSIS PROGRAM FOR TYPE 2 DIABETES"
},
"biosamples": [
"/primary-islet/PKBSM3365NRBV/",
"/human-beta-cell-line/PKBSM8703NVAT/",
"/human-beta-cell-line/PKBSM2324LQQD/",
"/human-beta-cell-line/PKBSM1679UWVX/",
"/human-beta-cell-line/PKBSM9444BMDZ/",
"/primary-islet/PKBSM7089UOBH/"
],
"bmi": 28.12,
"c_peptide": 5.91,
"cause_of_death": "Head trauma",
"center_donor_id": "SAMN25600002",
"collections": [
"HPAP"
],
"creation_timestamp": "2024-10-14T22:35:05.546329+00:00",
"data_available": [
{
"dataset": "Genotyping",
"dataset_link": "https://www.ncbi.nlm.nih.gov/projects/gap/cgi-bin/study.cgi?study_id=phs002465.v1.p1",
"dataset_tissue": "-"
},
{
"dataset": "HLA_typing",
"dataset_link": "https://www.ncbi.nlm.nih.gov/projects/gap/cgi-bin/study.cgi?study_id=phs002465.v1.p1",
"dataset_tissue": "-"
},
{
"dataset": "scRNAseq",
"dataset_link": "https://hpap.pmacs.upenn.edu",
"dataset_tissue": "Islet"
},
{
"dataset": "snATACseq",
"dataset_link": "https://hpap.pmacs.upenn.edu",
"dataset_tissue": "Islet"
},
{
"dataset": "Function",
"dataset_link": "https://hpap.pmacs.upenn.edu",
"dataset_tissue": "Islet"
},
{
"dataset": "Imaging",
"dataset_link": "https://hpap.pmacs.upenn.edu",
"dataset_tissue": "Islet"
},
{
"dataset": "histology",
"dataset_link": "https://hpap.pmacs.upenn.edu",
"dataset_tissue": "Pancreas"
},
{
"dataset": "CODEX",
"dataset_link": "https://hpap.pmacs.upenn.edu",
"dataset_tissue": "Pancreas"
},
{
"dataset": "imaging_mass_spec",
"dataset_link": "https://hpap.pmacs.upenn.edu",
"dataset_tissue": "Pancreas"
},
{
"dataset": "histology",
"dataset_link": "https://hpap.pmacs.upenn.edu",
"dataset_tissue": "Spleen"
},
{
"dataset": "histology",
"dataset_link": "https://hpap.pmacs.upenn.edu",
"dataset_tissue": "Lymph"
}
],
"data_available_datasets": [
"Genotyping",
"HLA_typing",
"scRNAseq",
"snATACseq",
"Function",
"Imaging",
"Histology",
"CODEX",
"imaging_mass_spec"
],
"data_available_keys": [
"Genotyping|unspecified",
"HLA_typing|unspecified",
"scRNAseq|Islet",
"snATACseq|Islet",
"Function|Islet",
"Imaging|Islet",
"Histology|Pancreas",
"CODEX|Pancreas",
"imaging_mass_spec|Pancreas",
"Histology|Spleen",
"Histology|Lymph"
],
"data_available_tissues": [
"unspecified",
"Islet",
"Pancreas",
"Spleen",
"Lymph"
],
"dbxrefs": [
"PANC-DB:HPAP-106"
],
"derived_diabetes_status": "Prediabetes",
"description": "Human pancreas donor SAMN25600002 in the HPAP database",
"diabetes_duration": "3",
"diabetes_status": [
"/phenotype-terms/MONDO_0005148/"
],
"diabetes_status_description": "Type 2 Diabetes",
"dominant_genetic_ancestry": "European",
"donation_type": "Donation after circulatory death",
"ethnicities": [
"White"
],
"family_history_of_diabetes": "TRUE",
"family_history_of_diabetes_relationship": [
"Mother"
],
"gender": "Male",
"genetic_ethnicities": [
{
"ethnicity": "European",
"percentage": 98
},
{
"ethnicity": "Admixed-American",
"percentage": 2
}
],
"genetic_sex": "Male",
"hba1c": 5.8,
"hla_status": "DR3/X",
"hla_typing": [
"A,1-24,RT-PCR",
"B,8-39,RT-PCR",
"Bw4,0-0,RT-PCR",
"Bw6,1-1,RT-PCR",
"C,07-07,RT-PCR",
"DPB1,02:01-04:01,RT-PCR",
"DQA1,01-05,RT-PCR",
"DQB1,2-5,RT-PCR",
"DR,01:03-17,RT-PCR",
"DR51,0-0,RT-PCR",
"DR52,52-52,RT-PCR",
"DR53,0-0,RT-PCR"
],
"hospital_stay": 53,
"human_donor_identifiers": [
"PANC-DB:HPAP-106"
],
"lab": {
"@id": "/labs/klaus-kaestner/"
},
"label_hba1c_discordant": false,
"living_donor": false,
"notes": "other disease states: Hyperlipidemia, Hypertension",
"other_therapy": [
"Metformin"
],
"other_tissues_available": [
"/sample-terms/UBERON_0002113/",
"/sample-terms/UBERON_0002107/",
"/sample-terms/UBERON_0002048/",
"/sample-terms/UBERON_0001264/",
"/sample-terms/UBERON_0000160/"
],
"pancreas_tissue_available": true,
"pediatric": false,
"publication_identifiers": [
"PMID:31127054",
"PMID:36206763"
],
"release_timestamp": "2025-01-10T01:41:39.889972+00:00",
"rrid": "RRID:SAMN25600002",
"schema_version": "23",
"sex_discordant": false,
"status": "released",
"submitted_by": {
"@id": "/users/5e3038c4-baa5-4589-b3d8-ad2fe634e826/",
"title": "Ying Sun"
},
"submitter_comment": "Meta-data was obtained directly from PANC-DB",
"summary": "PKBDO8380DZQP",
"t1d_stage": "No sufficient information to derive",
"taxa": "Homo sapiens",
"tier1_complete": true,
"url": "https://hpap.pmacs.upenn.edu/explore/donor/donor-summary/HPAP-106",
"uuid": "fa57835c-7c86-4551-ac5f-e3b425cffa48",
"virtual": false
}
Supported by National Institutes of Health (NIH) grants U24 DK138515, U24 DK138512
Supplemental funds from the NIH Office of Data Science Strategies
Supplemental funds from the NIH Office of Data Science Strategies
