PKBDO3406ZAZD
{
"@context": "/terms/",
"@id": "/human-donors/PKBDO3406ZAZD/",
"@type": [
"HumanDonor",
"Donor",
"Item"
],
"aab_count": 0,
"aab_gada": false,
"aab_gada_assay": [],
"aab_gada_value": 1,
"aab_ia2": false,
"aab_ia2_assay": [],
"aab_ia2_value": 3,
"aab_iaa": false,
"aab_iaa_assay": [],
"aab_iaa_value": 0.004,
"aab_positive": false,
"aab_summary": "none positive",
"aab_tested": true,
"aab_znt8": false,
"aab_znt8_assay": [],
"aab_znt8_value": 0.009,
"accession": "PKBDO3406ZAZD",
"age": 18,
"age_group": "18-39",
"aliases": [
"klaus-kaestner:HPAP-030"
],
"audit": {
"WARNING": [
{
"category": "missing tier 1 field",
"detail": "Human donor [PKBDO3406ZAZD](/human-donors/PKBDO3406ZAZD/) is missing tier 1 field `sex`.",
"level": 40,
"level_name": "WARNING",
"name": "audit_tier1_fields",
"path": "/human-donors/PKBDO3406ZAZD/"
},
{
"category": "missing tier 2 field",
"detail": "Human donor [PKBDO3406ZAZD](/human-donors/PKBDO3406ZAZD/) is missing tier 2 field `glucose_loweing_theraphy`.",
"level": 40,
"level_name": "WARNING",
"name": "audit_tier2_fields",
"path": "/human-donors/PKBDO3406ZAZD/"
},
{
"category": "missing tier 3 field",
"detail": "Human donor [PKBDO3406ZAZD](/human-donors/PKBDO3406ZAZD/) is missing tier 3 field `phenotypic_features`.",
"level": 40,
"level_name": "WARNING",
"name": "audit_tier3_fields",
"path": "/human-donors/PKBDO3406ZAZD/"
},
{
"category": "missing tier 3 field",
"detail": "Human donor [PKBDO3406ZAZD](/human-donors/PKBDO3406ZAZD/) is missing tier 3 field `family_history_of_diabetes_relationship`.",
"level": 40,
"level_name": "WARNING",
"name": "audit_tier3_fields",
"path": "/human-donors/PKBDO3406ZAZD/"
},
{
"category": "missing tier 3 field",
"detail": "Human donor [PKBDO3406ZAZD](/human-donors/PKBDO3406ZAZD/) is missing tier 3 field `other_therapy`.",
"level": 40,
"level_name": "WARNING",
"name": "audit_tier3_fields",
"path": "/human-donors/PKBDO3406ZAZD/"
},
{
"category": "missing tier 3 field",
"detail": "Human donor [PKBDO3406ZAZD](/human-donors/PKBDO3406ZAZD/) is missing tier 3 field `documents`.",
"level": 40,
"level_name": "WARNING",
"name": "audit_tier3_fields",
"path": "/human-donors/PKBDO3406ZAZD/"
},
{
"category": "missing tier 3 field",
"detail": "Human donor [PKBDO3406ZAZD](/human-donors/PKBDO3406ZAZD/) is missing tier 3 field `related_donors`.",
"level": 40,
"level_name": "WARNING",
"name": "audit_tier3_fields",
"path": "/human-donors/PKBDO3406ZAZD/"
}
]
},
"award": {
"@id": "/awards/UC4DK112217/",
"name": "UC4DK112217",
"title": "PENN INTEGRATED HUMAN PANCREAS PROCUREMENT AND ANALYSIS PROGRAM"
},
"biosamples": [
"/primary-islet/PKBSM0947XOUI/"
],
"bmi": 21.3,
"c_peptide": 0.09,
"cause_of_death": "Anoxia",
"center_donor_id": "SAMN19776461",
"collections": [
"HPAP"
],
"creation_timestamp": "2024-12-03T20:15:43.846721+00:00",
"data_available": [
{
"dataset": "Genotyping",
"dataset_link": "https://www.ncbi.nlm.nih.gov/projects/gap/cgi-bin/study.cgi?study_id=phs002465.v1.p1",
"dataset_tissue": "-"
},
{
"dataset": "HLA_typing",
"dataset_link": "https://www.ncbi.nlm.nih.gov/projects/gap/cgi-bin/study.cgi?study_id=phs002465.v1.p1",
"dataset_tissue": "-"
},
{
"dataset": "histology",
"dataset_link": "https://hpap.pmacs.upenn.edu",
"dataset_tissue": "Pancreas"
},
{
"dataset": "CODEX",
"dataset_link": "https://hpap.pmacs.upenn.edu",
"dataset_tissue": "Pancreas"
},
{
"dataset": "imaging_mass_spec",
"dataset_link": "https://hpap.pmacs.upenn.edu",
"dataset_tissue": "Pancreas"
},
{
"dataset": "TCRseq",
"dataset_link": "https://hpap.pmacs.upenn.edu",
"dataset_tissue": "Spleen"
},
{
"dataset": "BCRseq",
"dataset_link": "https://hpap.pmacs.upenn.edu",
"dataset_tissue": "Spleen"
},
{
"dataset": "Flow_cytometry",
"dataset_link": "https://hpap.pmacs.upenn.edu",
"dataset_tissue": "Spleen"
},
{
"dataset": "histology",
"dataset_link": "https://hpap.pmacs.upenn.edu",
"dataset_tissue": "Spleen"
},
{
"dataset": "scMultiome",
"dataset_link": "https://hpap.pmacs.upenn.edu",
"dataset_tissue": "Lymph"
},
{
"dataset": "Flow_cytometry",
"dataset_link": "https://hpap.pmacs.upenn.edu",
"dataset_tissue": "Lymph"
},
{
"dataset": "histology",
"dataset_link": "https://hpap.pmacs.upenn.edu",
"dataset_tissue": "Lymph"
},
{
"dataset": "Flow_cytometry",
"dataset_link": "https://hpap.pmacs.upenn.edu",
"dataset_tissue": "Peripheral_blood"
}
],
"data_available_datasets": [
"Genotyping",
"HLA_typing",
"Histology",
"CODEX",
"imaging_mass_spec",
"TCRseq",
"BCRseq",
"Flow_cytometry",
"scMultiome",
"snATACseq",
"scRNAseq"
],
"data_available_keys": [
"Genotyping|unspecified",
"HLA_typing|unspecified",
"Histology|Pancreas",
"CODEX|Pancreas",
"imaging_mass_spec|Pancreas",
"TCRseq|Spleen",
"BCRseq|Spleen",
"Flow_cytometry|Spleen",
"Histology|Spleen",
"scMultiome|Lymph",
"snATACseq|Lymph",
"scRNAseq|Lymph",
"Flow_cytometry|Lymph",
"Histology|Lymph",
"Flow_cytometry|Peripheral_blood"
],
"data_available_tissues": [
"unspecified",
"Pancreas",
"Spleen",
"Lymph",
"Peripheral_blood"
],
"dbxrefs": [
"PANC-DB:HPAP-030"
],
"derived_diabetes_status": "Diabetes",
"description": "Human donor SAMN19776461 in the HPAP database",
"diabetes_duration": "5",
"diabetes_status": [
"/phenotype-terms/MONDO_0005147/"
],
"diabetes_status_description": "Type 1 Diabetes",
"dominant_genetic_ancestry": "European",
"donation_type": "Donation after brain death",
"ethnicities": [
"White"
],
"family_history_of_diabetes": "-",
"gender": "Male",
"genetic_ethnicities": [
{
"ethnicity": "European",
"percentage": 99
},
{
"ethnicity": "Admixed-American",
"percentage": 1
}
],
"genetic_sex": "Male",
"hba1c": 12.4,
"hla_typing": [
"A,02:01-25:01,NGS",
"B,07:02-35:01,NGS",
"C,04:01-07:02,NGS",
"DPA1,01:03-.,NGS",
"DPB1,04:01-06:01,NGS",
"DQA1,03:01-05:01,NGS",
"DQB1,02:01-03:02,NGS",
"DRB1,03:01-04:04,NGS",
"DRB3,01:01-.,NGS",
"DRB4,01:03-.,NGS",
"DRB5,.-.,NGS",
"A,2-25,RT-PCR",
"B,7-35,RT-PCR",
"Bw4,0-0,RT-PCR",
"Bw6,1-1,RT-PCR",
"C,04-07,RT-PCR",
"DPB1,04:01-06:01,RT-PCR",
"DQA1,03:01-05:01,RT-PCR",
"DQB1,2-8,RT-PCR",
"DR,17-4,RT-PCR",
"DR51,0-.,RT-PCR",
"DR52,52-.,RT-PCR"
],
"hospital_stay": 117,
"human_donor_identifiers": [
"PANC-DB:HPAP-030"
],
"lab": {
"@id": "/labs/klaus-kaestner/"
},
"label_hba1c_discordant": false,
"living_donor": false,
"notes": "Cohort_ID:HPAP-030;addison's disease, hypothyroidism, autoimmune polyglandular failure, autism, asthma, celiac disease, adrenal crisis, seizures",
"other_tissues_available": [
"/sample-terms/UBERON_0002113/",
"/sample-terms/UBERON_0002107/",
"/sample-terms/UBERON_0002048/",
"/sample-terms/UBERON_0001264/",
"/sample-terms/UBERON_0000948/"
],
"pancreas_tissue_available": true,
"pediatric": false,
"publication_identifiers": [
"PMID:31127054",
"PMID:36206763"
],
"release_timestamp": "2025-01-10T01:41:09.384150+00:00",
"rrid": "RRID:SAMN19776461",
"schema_version": "23",
"sex_discordant": false,
"status": "released",
"submitted_by": {
"@id": "/users/5e3038c4-baa5-4589-b3d8-ad2fe634e826/",
"title": "Ying Sun"
},
"submitter_comment": "Meta-data was obtained directly from PANC-DB",
"summary": "PKBDO3406ZAZD",
"t1d_stage": "Stage 3: one or more autoantibodies and diagnostic hyperglycemia or T1D diagnosis",
"taxa": "Homo sapiens",
"tier1_complete": true,
"url": "https://hpap.pmacs.upenn.edu/explore/donor/donor-summary/HPAP-030",
"uuid": "dc6a5998-5f25-4017-a7b4-9bf9aba5f76d",
"virtual": false
}
Supported by National Institutes of Health (NIH) grants U24 DK138515, U24 DK138512
Supplemental funds from the NIH Office of Data Science Strategies
Supplemental funds from the NIH Office of Data Science Strategies
