released

PKBDO1384BFXE

released

RRID RRID:SAMN19776485Program Donor ID SAMN19776485

Clinical summary

Diabetes status

Type 1 Diabetes

Age (y)

Age group

18-39

BMI

27.9

Height (cm)

—

Weight (kg)

—

HbA1c %

10.4

C-Peptide (ng/ml)

0.02

Diabetes duration

AAB summary

GADA+, IAA+, IA2+, ZNT8+

AAB count

Age (y): 24
Age group: 18-39
Pediatric: No
Gender: Male
Genetic Sex: Male
Sex discordant: No
Ethnicity: Hispanic
Predicted genetic ancestry: Admixed-American (70%), African (24%), European (4%), South-Asian (2%)
Dominant genetic ancestry: Admixed-American

Diabetes (ontology): MONDO:0005147
T1D stage: Stage 3: one or more autoantibodies and diagnostic hyperglycemia or T1D diagnosis
HbA1c-derived diabetes status: Diabetes
Label vs HbA1c discordant: No
Tier 1 complete: Yes
Family history of diabetes: TRUE
Family history relationship: Maternal_grandmother, Maternal_aunt
Living donor: No
Cause of death: Anoxia
Donation type: Donation after brain death
Hospital stay (h): 79
Medication: Insulin

GADAPositive

55 unit/ml

IAAPositive

0.013 unit/ml

IA2Positive

255 unit/ml

ZNT8Positive

1.099 unit/ml

Status: DR3/DR4

Locus	Allele 1	Allele 2	Method
A	02:01	02:01	NGS
A	2	2	RT-PCR
B	08:01	39:08	NGS
B	8	39	RT-PCR
Bw4	0	0	RT-PCR
Bw6	1	1	RT-PCR
C	07	07	RT-PCR
C	07:01	07:02	NGS
DPA1	01:03	02:01	NGS
DPB1	01:01	04:02	NGS
DPB1	01:01	04:02	RT-PCR
DQA1	03	05	RT-PCR
DQA1	03:01	05:01	NGS
DQB1	02:01	03:02	NGS
DQB1	2	8	RT-PCR
DR	17	4	RT-PCR
DR51	0	0	RT-PCR
DR52	52	0	RT-PCR
DR53	53	0	RT-PCR
DRB1	03:01	04:07	NGS
DRB3	01:01	—	NGS
DRB4	—	01:03	NGS
DRB5	—	—	NGS

Datasets: Genotyping, HLA_typing, RNAseq, scRNAseq, snATACseq, Function, Imaging, CyTof, Histology, CODEX, imaging_mass_spec, TCRseq, BCRseq, Flow_cytometry
Tissues: unspecified, Islet, Pancreas, Spleen, Lymph, Peripheral_blood